Factory supply 99% Retinoic acid / Vitamin A Acid /Tretinoin

Factory supply 99% Retinoic acid / Vitamin A Acid /Tretinoin Product Name Tretinoin CAS No. 302-79-4 EINECS No. 206-129-0 Molecualr Formula C20H27O2 Appearance yellowish powder Water-solubility insoluble Grade Pharma Grade High quality retinoic acid powder CAS:302-79-4 Tretinoin Retinoic acid function in the absence of precursors retinol or retinaldehyde Retinoic acid is responsible for most of the activity of vitamin A, save visual pigment effects that require retinal (retinaldehyde), and cell metabolism effects that may require retinol itself. Also, some biochemical functions necessary for fertility in vitamin A deficient male and female mammals originally appeared to require retinol for rescue, but this is due to a requirement for local conversion of retinol to retinoic acid, as administered retinoic acid does not reach some critical tissues unless given in high amounts. Thus, if animals are fed only retinoic acid but no vitamin A (retinol or retinal), they suffer none of the growth-stunting or epithelial-damaging effects of lack of vitamin A (including no xerophthalmia—dryness of the cornea). They do suffer retina degeneration and blindness, due toretinal (retinaldehyde) deficiency.   In addition, vitamin A-deprived but retinoic acid-supplemented male rats exhibit hypogonadism andinfertility due to lack of local retinoic acid synthesis in the testis; similar treatment of female rats causes infertility due to fetal resorption caused by a lack of local retinoic acid synthesis in the embryo. The retinoic acid synthesis in testes is catalyzed primarily by the RALDH2 (ALDH1A2) aldehyde dehydrogenase. Suppressing this enzyme has been proposed as a possible way to make a male contraceptive pill, because retionic acid is necessary for spermatogenesis in humans much like in rats.   ITEMS SPECIFICATIONS DESCRIPTION YELLOW TO LIGHT-ORANGE CRYSTALLINE POWDER IDENTIFICATION:A B UV IR LOSS ON DRYING NOT MORE THAN 0.5% RESIDUE ON IGNITION NOT MORE THAN 0.1% HEAVY METALS NOT MORE THAN 0.002% LIMIT OF ISOTRETINOIN ACID NOT MORE THAN 5.0% ASSAY (ON THE ANHYDROUS BASIS) 98.0%-102%